Microglia Biology: One Century of Evolving Concepts
| Autor: | Josef Priller, Steffen Jung, Marco Prinz |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Neurogenesis
Population Disease Biology metabolism [Microglia] General Biochemistry Genetics and Molecular Biology etiology [Neurodegenerative Diseases] 03 medical and health sciences 0302 clinical medicine medicine cytology [Microglia] Animals Homeostasis Humans ddc:610 education 030304 developmental biology 0303 health sciences education.field_of_study Microglia Neurodegenerative Diseases 3. Good health physiology [Microglia] medicine.anatomical_structure nervous system Transcriptome Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Cell 179(2), 292-311 (2019). doi:10.1016/j.cell.2019.08.053 |
| ISSN: | 1097-4172 |
| DOI: | 10.1016/j.cell.2019.08.053 |
| Popis: | Microglia were first recognized as a distinct cell population in the CNS one century ago. For a long time, they were primarily considered to be phagocytes responsible for removing debris during CNS development and disease. More recently, advances in imaging and genetics and the advent of single-cell technologies provided new insights into the much more complex and fascinating biology of microglia. The ontogeny of microglia was identified, and their functions in health and disease were better defined. Although many questions about microglia and their roles in human diseases remain unanswered, the prospect of targeting microglia for the treatment of neurological and psychiatric disorders is tantalizing. |
| Databáze: | OpenAIRE |
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