Arterial disease in lupus and secondary antiphospholipid syndrome: association with anti-beta2-glycoprotein I antibodies but not with antibodies against oxidized low-density lipoprotein
| Autor: | Ma. Khamashta, G. R. V. Hughes, Olga Amengual, Tatsuya Atsumi, Francisco J. Tinahones, F I Romero |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Systemic disease Adolescent Arteriosclerosis Immunoglobulin G Rheumatology Immunopathology medicine Humans Lupus Erythematosus Systemic Beta 2-Glycoprotein I Pharmacology (medical) Child skin and connective tissue diseases Aged Autoantibodies Glycoproteins Systemic lupus erythematosus Lupus erythematosus biology business.industry Autoantibody Middle Aged Antiphospholipid Syndrome medicine.disease Connective tissue disease Lipoproteins LDL Apolipoproteins beta 2-Glycoprotein I Immunology biology.protein Female lipids (amino acids peptides and proteins) business Oxidation-Reduction |
| Zdroj: | Rheumatology. 37:883-888 |
| ISSN: | 1462-0332 1462-0324 |
| Popis: | SUMMARY The prevalence and clinical significance of antibodies against b 2 -glycoprotein I (anti-b 2 GPI ) and antibodies against oxidized low-density lipoprotein (anti-ox-LDL) were evaluated as potential indicators of arterial disease in patients with systemic lupus erythematosus (SLE) and SLE with secondary antiphospholipid syndrome (APS). IgG anti-b 2 GPI and IgG anti-ox-LDL were measured by enzyme-linked immunosorbent assay (ELISA) in serum samples from 118 patients with SLE, including 40 with secondary APS. IgG anti-b 2 GPI were positive in 17% (20/118) of SLE patients. The presence and titres of IgG anti-b 2 GPI were strongly associated with a history of arterial thrombosis. Haemolytic anaemia was also significantly associated with the presence of IgG anti-b 2 GPI. The prevalence of IgG anti-ox-LDL was 53% (63/118), but there was no association with arterial thrombosis. No correlation between the values of anti-ox-LDL and those of anti-b 2 GPI was found. These results suggest that IgG anti-b 2 GPI could be a marker for arterial thrombosis in SLE patients, while IgG anti-ox-LDL were not associated with arterial disease in this group of lupus patients. |
| Databáze: | OpenAIRE |
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