Evaluation of tuberculosis diagnostic biomarkers in immunocompromised hosts based on cytokine levels in QuantiFERON-TB Gold Plus
| Autor: | Sahoko Imoto, Maho Suzukawa, Keita Takeda, Takumi Motohashi, Maki Nagase, Yu Enomoto, Yuichiro Kawasaki, Eri Nakano, Masato Watanabe, Masahiro Shimada, Kazufumi Takada, Shizuka Watanabe, Takahide Nagase, Ken Ohta, Katsuji Teruya, Hideaki Nagai |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Microbiology (medical)
Immunology Receptors Interleukin-1 Mycobacterium tuberculosis Microbiology Immunocompromised Host Interferon-gamma Interleukin 1 Receptor Antagonist Protein Infectious Diseases Latent Tuberculosis Cytokines Humans Interleukin-2 Tuberculosis Biomarkers Chemokine CCL2 Interferon-gamma Release Tests |
| Zdroj: | Tuberculosis (Edinburgh, Scotland). 136 |
| ISSN: | 1873-281X |
| Popis: | Tuberculosis (TB) remains a serious health concern globally. QuantiFERON-TB (QFT) is a diagnostic tool for TB detection, and its sensitivity is reduced in immunocompromised hosts with low T lymphocyte counts or abnormal T cell function. This study aimed to evaluate the correlation between T cell and cytokine levels in patients with active TB using QFT-Plus. Forty-five patients with active TB were enrolled, and the cytokines in QFT-Plus tube supernatants were quantified using the MAGPIX System. CD4 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect