Dynamics of dendritic cell-T cell interactions: a role in T cell outcome
| Autor: | Stéphanie Hugues |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Dendritic Cells/*immunology
T-Lymphocytes T cell Immunology Cell Priming (immunology) Cell Communication In Vitro Techniques Biology ddc:616.07 Lymphocyte Activation Cell Communication/*immunology 03 medical and health sciences 0302 clinical medicine Cell–cell interaction Cell Movement T-Lymphocytes/*immunology medicine Immune Tolerance Immunology and Allergy Animals Humans Lymph Nodes/cytology/immunology Antigen-presenting cell 030304 developmental biology 0303 health sciences Antigen Presentation Models Immunological Dendritic Cells Dendritic cell T lymphocyte 3. Good health Cell biology Tolerance induction Microscopy Fluorescence Multiphoton medicine.anatomical_structure Cell Movement/immunology Microscopy Fluorescence Multiphoton/methods Lymph Nodes 030215 immunology |
| Zdroj: | Seminars in Immunopathology, Vol. 32, No 3 (2010) pp. 227-238 Seminars in immunopathology |
| ISSN: | 1863-2297 |
| Popis: | Antigen-specific dendritic cells (DC)-T cell encounters occur in lymph nodes (LNs) and are essential for the induction of both priming and tolerance. In both cases, T cells are rapidly activated and proliferate. However, the subsequent outcome of T cell activation depends on the modulation of different DC- and T cell-intrinsic signals. Recent advances in two-photon (2P) microscopy have furthered our understanding regarding the complex choreography of DCs and T cells in intact LNs, and established differences in the dynamics of DC-T cell contacts during priming and tolerance induction. The mechanisms that favour DC-T cell encounters, as well as the contribution of the frequency and the duration of such encounters in dictating the T cell response, are discussed in this review. |
| Databáze: | OpenAIRE |
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