Role of targeted therapies in rheumatic patients on COVID-19 outcomes: Results from the COVIDSER study

Autor: Jose María Álvaro Gracia, Carlos Sanchez-Piedra, Javier Manero, María Ester Ruiz-Lucea, Laura López-Vives, Cristina Bohorquez, Julia Martinez-Barrio, Gema Bonilla, Paloma Vela, María Jesús García-Villanueva, María Teresa Navío-Marco, Marina Pavía, María Galindo, Celia Erausquin, Miguel A Gonzalez-Gay, Inigo Rua-Figueroa, Jose M Pego-Reigosa, Isabel Castrejon, Jesús T Sanchez-Costa, Enrique González-Dávila, Federico Diaz-Gonzalez
Přispěvatelé: Universidad de Cantabria
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: RMD Open
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
RMD Open . 2021 Dec;7(3):e001925.
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
Popis: ObjectivesTo analyse the effect of targeted therapies, either biological (b) disease-modifying antirheumatic drugs (DMARDs), targeted synthetic (ts) DMARDs and other factors (demographics, comorbidities or COVID-19 symptoms) on the risk of COVID-19 related hospitalisation in patients with inflammatory rheumatic diseases.MethodsThe COVIDSER study is an observational cohort including 7782 patients with inflammatory rheumatic diseases. Multivariable logistic regression was used to estimate ORs and 95% CIs of hospitalisation. Antirheumatic medication taken immediately prior to infection, demographic characteristics, rheumatic disease diagnosis, comorbidities and COVID-19 symptoms were analysed.ResultsA total of 426 cases of symptomatic COVID-19 from 1 March 2020 to 13 April 2021 were included in the analyses: 106 (24.9%) were hospitalised and 19 (4.4%) died. In multivariate-adjusted models, bDMARDs and tsDMARDs in combination were not associated with hospitalisation compared with conventional synthetic DMARDs (OR 0.55, 95% CI 0.24 to 1.25 of b/tsDMARDs, p=0.15). Tumour necrosis factor inhibitors (TNF-i) were associated with a reduced likelihood of hospitalisation (OR 0.32, 95% CI 0.12 to 0.82, p=0.018), whereas rituximab showed a tendency to an increased risk of hospitalisation (OR 4.85, 95% CI 0.86 to 27.2). Glucocorticoid use was not associated with hospitalisation (OR 1.69, 95% CI 0.81 to 3.55). A mix of sociodemographic factors, comorbidities and COVID-19 symptoms contribute to patients’ hospitalisation.ConclusionsThe use of targeted therapies as a group is not associated with COVID-19 severity, except for rituximab, which shows a trend towards an increased risk of hospitalisation, while TNF-i was associated with decreased odds of hospitalisation in patients with rheumatic disease. Other factors like age, male gender, comorbidities and COVID-19 symptoms do play a role.
Databáze: OpenAIRE
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