Assessment of HLADP gene rs3128917 and rs9380343 polymorphisms in chronic HBV infection
| Autor: | Ersin Akgöllü |
|---|---|
| Přispěvatelé: | Çukurova Üniversitesi |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male HLA-DP Antigens Adolescent Genotype Turkey Genome-wide association study Rs9380343 Human leukocyte antigen Polymorphism Single Nucleotide Rs3128917 Hepatitis B Chronic Antigen Polymorphism (computer science) Humans Medicine Allele Alleles HBV infection Aged Genetic association Aged 80 and over business.industry Gastroenterology Middle Aged Hepatitis B medicine.disease HLA polymorphism Immunology Original Article Female business |
| Zdroj: | The Turkish Journal of Gastroenterology. 30:616-623 |
| ISSN: | 2148-5607 1300-4948 |
| DOI: | 10.5152/tjg.2019.18480 |
| Popis: | PubMedID: 31290749 Background/Aims: About 400 million people worldwide have been exposed to Hepatitis B (HBV) infection. A range of 10%-15% of chronic HBV carriers may present with various liver diseases including cirrhosis and hepatic cancer. The chronicity or clearance of HBV infection is dependent on viral and genetic variables. Genome-wide association studies (GWAS) have reported that the variants of human leukocyte antigen (HLA), rs3128917 and rs9380343, are significantly related to persistent HBV infection. HLA molecules are responsible for introducing various antigens into the immune system. These variants might affect antigen presentation by influencing HLA mRNA expression, therefore, antigen presentation may not be performed properly. This study aims to assess the relationship of HLA gene variants to chronic HBV infection. Materials and Methods: HLA variants were explored in 238 chronic HBV patients and in 238 individuals with spontaneous clearance of HBV using PCR-RFLP assay. Results: The allele and genotype of rs9380343 polymorphism were associated with persistent HBV infection risk (allele: p=0.038, genotype: p=0.029), but rs3128917 polymorphism was not significant. Additionally, rs9380343 polymorphism was also related to increased risk of HBV infection in males (p |
| Databáze: | OpenAIRE |
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