A role for descending auditory cortical projections in songbird vocal learning
| Autor: | Yael Mandelblat-Cerf, Natalia Denisenko, Michale S. Fee, Liora Las |
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| Přispěvatelé: | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences, McGovern Institute for Brain Research at MIT, Mandelblat-Cerf, Yael, Las, Liora, Denisenko, Natasha, Fee, Michale S., Denissenko, Natalia, Fee, Michale Sean |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Auditory Pathways Memorization Key (music) 0302 clinical medicine Feedback Sensory Mesencephalon Praise Biology (General) media_common Neurons 0303 health sciences biology General Neuroscience vocal learning Brain General Medicine error signal behavior and behavior mechanisms Medicine Singing Psychology psychological phenomena and processes Research Article Arcopallium animal structures QH301-705.5 media_common.quotation_subject Science education Auditory cortex General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Reward Memory Animals Learning 030304 developmental biology Auditory Cortex Communication General Immunology and Microbiology business.industry Dopaminergic Neurons other biology.organism_classification songbird Songbird Acoustic Stimulation nervous system Vocal learning Finches Vocalization Animal business 030217 neurology & neurosurgery Neuroscience |
| Zdroj: | eLife Sciences Publications, Ltd. eLife eLife, Vol 3 (2014) |
| Popis: | Many learned motor behaviors are acquired by comparing ongoing behavior with an internal representation of correct performance, rather than using an explicit external reward. For example, juvenile songbirds learn to sing by comparing their song with the memory of a tutor song. At present, the brain regions subserving song evaluation are not known. In this study, we report several findings suggesting that song evaluation involves an avian 'cortical' area previously shown to project to the dopaminergic midbrain and other downstream targets. We find that this ventral portion of the intermediate arcopallium (AIV) receives inputs from auditory cortical areas, and that lesions of AIV result in significant deficits in vocal learning. Additionally, AIV neurons exhibit fast responses to disruptive auditory feedback presented during singing, but not during nonsinging periods. Our findings suggest that auditory cortical areas may guide learning by transmitting song evaluation signals to the dopaminergic midbrain and/or other subcortical targets. National Institutes of Health (U.S.) (grant R01 MH067105) McGovern Institute for Brain Research at MIT (Internal funding) |
| Databáze: | OpenAIRE |
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