Remission of Late-Onset Post-Liver Transplantation Non-Hodgkin Lymphoma
| Autor: | Magdalena Genadieva Dimitrova, Vladimir Serafimoski, Sonja Genco Genadieva Stavrik, Rozalinda Popova Jovanovska, Aleksandar Stojanovik, Neda Milevska Kostova, Kalina Grivcheva Stardelova |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
medicine.medical_specialty medicine.medical_treatment Lymphoproliferative disorders Late onset 030230 surgery Liver transplantation CHOP Gastroenterology 03 medical and health sciences Antineoplastic Agents Immunological 0302 clinical medicine hemic and lymphatic diseases Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Cyclophosphamide business.industry Lymphoma Non-Hodgkin Remission Induction Immunosuppression General Medicine medicine.disease Lymphoproliferative Disorders Liver Transplantation Lymphoma Transplantation Doxorubicin Vincristine 030220 oncology & carcinogenesis Cyclosporine Prednisone Female Rituximab business Immunosuppressive Agents medicine.drug |
| Zdroj: | PRILOZI. 40:67-71 |
| ISSN: | 1857-8985 1857-9345 |
| Popis: | We describe the clinical course of a patient who developed high-grade lymphoma during immunosuppression treatment with cyclosporine A, following liver transplantation. After anti-neoplastic polychemotherapy treatment, the remission of lymphoma was confirmed and maintained for over four years. The patient, a 27 year old female had liver transplantation at the age of 17, due to acute liver failure, caused by non-diagnosed Wilson disease. Nearly seven years post-transplantation, the patient was diagnosed with non-Hodgkin B-cell lymphoma (NHBCL), potentially induced by Cephalosporin A therapy. After the treatment with rituximab and CHOP therapy (r-CHOP protocol), remission was determined using computer tomography. Remission is maintained to date. A review of reported cases of post-transplant lymphoproliferative disorders (PTLDs) in liver transplanted (LT) patients showed that the onset of PTLDs is the highest in the first year after transplantation. In addition, remission rates of NHBCL in LT patients are not much elaborated in the literature. It is our opinion that the presented case is rare, both from the aspect of timeline of occurrence of the PTLD and the achieved remission, using r-CHOP protocol. |
| Databáze: | OpenAIRE |
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