EXPOSURE TO ENVIRONMENTAL TOBACCO SMOKE INDUCES ANGIOGENESIS AND LEUKOCYTE TRAFFICKING IN LUNG MICROVESSELS

Autor:	Savita P. Rao, P. Sriramarao, Lyudmila Sikora, Kent E. Pinkerton, M. Reza Hosseinkhani
Rok vydání:	2009
Předmět:	Pulmonary and Respiratory Medicine Pathology medicine.medical_specialty Neutrophils Angiogenesis Clinical Biochemistry Leukocyte Rolling Article Tobacco smoke Nicotine Mice Leukocyte Trafficking Cell Adhesion Leukocytes medicine Animals Lung Molecular Biology Inflammation COPD Neovascularization Pathologic business.industry respiratory system medicine.disease respiratory tract diseases Chemotaxis Leukocyte medicine.anatomical_structure Microvessels Immunology Tobacco Smoke Pollution business Intravital microscopy medicine.drug
Zdroj:	Experimental Lung Research. 35:119-135
ISSN:	1521-0499 0190-2148
DOI:	10.1080/01902140802449729
Popis:	Exposure to environmental tobacco smoke (ETS) is known to contribute to and exacerbate inflammatory diseases of the lung such as chronic obstructive pulmonary disease (COPD) and asthma. The effect of ETS on angiogenesis and leukocyte recruitment, both of which promote lung inflammation, was investigated using lung tissue from mice exposed to aged and diluted sidestream cigarette smoke or fresh air for 12 weeks and transplanted into dorsal skin-fold chambers in nude mice. Lung tissue from mice exposed to cigarette smoke for 12 weeks exhibited significantly increased vascular density (angiogenesis) associated with selectin-mediated increased intravascular leukocyte rolling and adhesion compared to fresh air–exposed lung tissue by intravital microscopy. Further, neutrophils from nicotine-exposed mice displayed significantly increased rolling and adhesion compared to control neutrophils in microvessels of nicotine-exposed lungs versus control lung microvessels, suggesting that nicotine in cigarette smoke can augment leukocyte-endothelial interactions. ETS-induced angiogenesis and leukocyte trafficking may play a key role in airway recruitment of inflammatory cells in ETS-associated disorders such as COPD bronchitis or asthma.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56c1671828e67109068b56ceb8099c2b https://doi.org/10.1080/01902140802449729 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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