The value of serum neopterin, interferon-gamma levels and interleukin-12B polymorphisms in predicting acute renal allograft rejection
| Autor: | B. S. Carey, E. R. Kaminski, G. K. Chin, W.-Y. Tse, Claire L. Adams, Steve Shaw |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Graft Rejection Male Translational Studies Immunology Neopterin Polymerase Chain Reaction Polymorphism Single Nucleotide Interferon-gamma chemistry.chemical_compound Interferon Humans Immunology and Allergy Medicine Interferon gamma Retrospective Studies Creatinine Kidney Interleukin-12 Subunit p40 business.industry Interleukin Middle Aged Prognosis Kidney Transplantation Transplantation medicine.anatomical_structure chemistry Acute Disease Interleukin 12 Female business Biomarkers medicine.drug |
| Zdroj: | Clinical and Experimental Immunology. 152:239-244 |
| ISSN: | 1365-2249 0009-9104 |
| DOI: | 10.1111/j.1365-2249.2008.03632.x |
| Popis: | Summary Acute rejection remains a poor predictor of graft outcome. In this study, we measured serum levels of interferon (IFN)-γ and neopterin by enzyme-linked immunosorbent assay and a single nucleotide polymorphism (SNP) within the 3′ untranslated region of the interleukin (IL)-12 B gene (1188 A/C) to determine whether either of these factors could predict acute rejection in renal transplantation. Significantly higher early post-transplant neopterin levels (days 5–7; 35·7 versus 19·9 nmol/l) were observed in recipients who subsequently rejected their grafts. Post-transplant neopterin levels showed a strong positive correlation with 1-month creatinine levels (Spearman's correlation 0·62, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|