Family aggregation of mental disorders in the nationwide Danish three generation study
| Autor: | Gurli Perto, Povl Munk-Jørgensen, Hans-Christoph Steinhausen, Leslie Foldager |
|---|---|
| Přispěvatelé: | University of Zurich |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Affective Disorders Psychotic Male Parents medicine.medical_specialty Adolescent Child psychopathology Denmark 610 Medicine & health 2738 Psychiatry and Mental Health Young Adult Prevalence of mental disorders Cohort Effect medicine Odds Ratio 2736 Pharmacology (medical) Humans Pharmacology (medical) Family Psychiatry Child Biological Psychiatry Psychiatric Status Rating Scales Mental Disorders Siblings Family aggregation Infant General Medicine 10058 Department of Child and Adolescent Psychiatry medicine.disease Neuroticism Anxiety Disorders Substance abuse Psychiatry and Mental health Schizophrenia Case-Control Studies Child Preschool Anxiety Regression Analysis Female medicine.symptom Psychology 2803 Biological Psychiatry Psychopathology Clinical psychology Follow-Up Studies |
| Zdroj: | Steinhausen, H-C, Foldager, L, Perto, G & Munk-Jørgensen, P 2009, ' Family aggregation of mental disorders in the nationwide Danish three generation study ', European Archives of Psychiatry and Clinical Neuroscience, vol. 259, no. 5, pp. 270-277 . https://doi.org/10.1007/s00406-008-0865-0 |
| Popis: | Udgivelsesdato: August 2009 OBJECTIVE: The study of familial aggregation of major mental disorders in a national population. METHOD: Within a Danish register-based cohort study, aggregation of mental disorders was analysed in all case-probands with first psychiatric contact before the age of 19 years in the time period between 1 April 1969 and 29 June 2004 followed up until the age of 35 years, their first-degree relatives, and a matched group of control-probands including their first-degree relatives. RESULTS: Hazard rate ratios were significantly elevated for cases as compared to controls for all diagnoses among probands, parents, and siblings. Among children of the probands, these ratios were significantly elevated for neurotic (anxiety) disorders, mental retardation, developmental disorders, behavioural and emotional disorders of childhood and adolescence, and miscellaneous disorders. Family aggregation of any diagnosis was significantly higher in probands with substance use disorder, schizophrenia, affective disorders, neurotic (anxiety) disorders, and miscellaneous disorders. There was specificity of familial transmission for affective and neurotic (anxiety) disorders. CONCLUSION: This large nationwide study found some differential patterns of familial aggregation of major mental disorders. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|