Vascular Smooth Muscle Cell Maturation Stage and Ki-67 Index are Diagnostic Biomarkers for Pathologic Grade of Ovarian Teratoma
| Autor: | Hajime Horiuchi, Toshitaka Nagao, Masahiko Kuroda, Koji Fujita, Atsushi Kurata, Masako Hongo-Kohama, Hirotsugu Hashimoto |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
CD31 Adult endocrine system Pathology medicine.medical_specialty Vascular smooth muscle endocrine system diseases Adolescent Muscle Smooth Vascular Pathology and Forensic Medicine 03 medical and health sciences Young Adult 0302 clinical medicine medicine Humans Ovarian Teratoma Grading (tumors) Ovarian Neoplasms Neoplasm Grading biology Teratoma Obstetrics and Gynecology medicine.disease Prognosis Immunohistochemistry female genital diseases and pregnancy complications Actins 030104 developmental biology Ki-67 Antigen 030220 oncology & carcinogenesis Ki-67 biology.protein Immature teratoma Calmodulin-Binding Proteins Female Biomarkers |
| Zdroj: | International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. 36(6) |
| ISSN: | 1538-7151 |
| Popis: | Although immature teratoma of the ovary is a rare disease, its pathologic grading, especially between low-grade (grade 1) and high-grade (grade 2 or 3) immature teratomas, is important for optimal therapy and prognosis. This grading, however, is currently solely dependent on quantitation of neuroepithelial components as judged by subjective assessments. As we have recently successfully studied the maturation of vascular smooth muscle cells (SMCs) in other organs using an h-caldesmon to α-smooth muscle actin (α-SMA) ratio, we decided to use this ratio to investigate a potential link between teratoma grade and SMC maturation, in combination with Ki-67 index. Sixteen immature teratomas along with 5 mature teratomas of the ovary were studied and stained with antibodies to CD31, α-SMA, h-caldesmon, and Ki-67. The number of vascular SMCs calculated using the α-SMA/CD31 ratio did not differ between teratoma grades (except between grade 0 and 3), whereas the number of mature vascular SMCs calculated using the h-caldesmon/CD31 ratio and maturation state calculated using the h-caldesmon/α-SMA ratio reduced significantly as teratoma grade progressed from 0 to 3. Furthermore, these parameters were significantly lower in high-grade than in low-grade immature teratomas (P |
| Databáze: | OpenAIRE |
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