Evaluation of Platelet Parameters in Children with Autism Spectrum Disorder: Elongated Collagen‐Adenosine Diphosphate and Collagen‐Epinephrine Closure Times

Autor: Sinan Akbayram, Cem Gokcen, Baran Calisgan, Nurdan Coban
Rok vydání: 2019
Předmět:
Male
medicine.medical_specialty
Adolescent
Epinephrine
Platelet Function Tests
Turkey
Autism Spectrum Disorder
behavioral disciplines and activities
03 medical and health sciences
0302 clinical medicine
Internal medicine
mental disorders
medicine
Humans
0501 psychology and cognitive sciences
Mean platelet volume
Child
Genetics (clinical)
Prothrombin time
medicine.diagnostic_test
business.industry
General Neuroscience
05 social sciences
Platelet Distribution Width
Complete blood count
medicine.disease
Blood Cell Count
Adenosine Diphosphate
Cross-Sectional Studies
Endocrinology
Autism spectrum disorder
Case-Control Studies
Child
Preschool
Prothrombin Time
Childhood Autism Rating Scale
Autism
Female
Partial Thromboplastin Time
Collagen
Neurology (clinical)
business
Mean Platelet Volume
030217 neurology & neurosurgery
050104 developmental & child psychology
Partial thromboplastin time
Zdroj: Autism Research. 12:1069-1076
ISSN: 1939-3806
1939-3792
Popis: Changes related to the serotonin system play a key role in the etiology of autism spectrum disorder (ASD). Although we know that platelets are associated with the serotonin system, their relation to ASD has not yet been elucidated. In this study, we aim to investigate platelet parameters in children with ASD. Forty patients with ASD according to Diagnostic and Statistical Manual of Mental Disorders 5 (DSM-5) and 30 healthy controls were included in the study. A complete blood count was done to measure parameters relating to platelet morphology. Moreover, prothrombin time (PT) and activated partial thromboplastin time (aPTT) were evaluated. Lastly, platelet functions were assessed with a platelet functions analyzer 100 (PFA-100) device by measuring collagen-ADP and collagen-epinephrine (EPI) closure times. There was not a significant difference between the groups in terms of platelet count, mean platelet volume (MPV), platelet distribution width, plateletcrit, PT, or aPTT parameters for ASD patients when compared to the control group (P > 0.05). However, MPV in severe ASD, as quantified by the Childhood Autism Rating Scale, was found to be significantly lower when compared to mild to moderate ASD (P = 0.047). Moreover, in terms of platelet functions, the elongation in collagen-ADP and collagen-EPI closure times were significantly higher for the ASD group (P = 0.044). These results may suggest an impairment in platelet functions rather than in platelet morphology for children with ASD. Considering these results, further investigation of thrombocyte functions in the ASD may lead to a better understanding of the pathogenesis of ASD and to the development of our limited knowledge of this disorder. Autism Res 2019, 12: 1069-1076. © 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Serotonin is a chemical that is found in brain as wells as in blood cells that function in blood clotting in the human body. There are problems related to serotonin in brains of people who have autism. Thus, blood clotting cells may also be affected in people who have autism. In this study, we compare blood clotting functions of children with autism with that of healthy controls.
Databáze: OpenAIRE
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