Evaluation of Platelet Parameters in Children with Autism Spectrum Disorder: Elongated Collagen‐Adenosine Diphosphate and Collagen‐Epinephrine Closure Times
Autor: | Sinan Akbayram, Cem Gokcen, Baran Calisgan, Nurdan Coban |
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Rok vydání: | 2019 |
Předmět: |
Male
medicine.medical_specialty Adolescent Epinephrine Platelet Function Tests Turkey Autism Spectrum Disorder behavioral disciplines and activities 03 medical and health sciences 0302 clinical medicine Internal medicine mental disorders medicine Humans 0501 psychology and cognitive sciences Mean platelet volume Child Genetics (clinical) Prothrombin time medicine.diagnostic_test business.industry General Neuroscience 05 social sciences Platelet Distribution Width Complete blood count medicine.disease Blood Cell Count Adenosine Diphosphate Cross-Sectional Studies Endocrinology Autism spectrum disorder Case-Control Studies Child Preschool Prothrombin Time Childhood Autism Rating Scale Autism Female Partial Thromboplastin Time Collagen Neurology (clinical) business Mean Platelet Volume 030217 neurology & neurosurgery 050104 developmental & child psychology Partial thromboplastin time |
Zdroj: | Autism Research. 12:1069-1076 |
ISSN: | 1939-3806 1939-3792 |
Popis: | Changes related to the serotonin system play a key role in the etiology of autism spectrum disorder (ASD). Although we know that platelets are associated with the serotonin system, their relation to ASD has not yet been elucidated. In this study, we aim to investigate platelet parameters in children with ASD. Forty patients with ASD according to Diagnostic and Statistical Manual of Mental Disorders 5 (DSM-5) and 30 healthy controls were included in the study. A complete blood count was done to measure parameters relating to platelet morphology. Moreover, prothrombin time (PT) and activated partial thromboplastin time (aPTT) were evaluated. Lastly, platelet functions were assessed with a platelet functions analyzer 100 (PFA-100) device by measuring collagen-ADP and collagen-epinephrine (EPI) closure times. There was not a significant difference between the groups in terms of platelet count, mean platelet volume (MPV), platelet distribution width, plateletcrit, PT, or aPTT parameters for ASD patients when compared to the control group (P > 0.05). However, MPV in severe ASD, as quantified by the Childhood Autism Rating Scale, was found to be significantly lower when compared to mild to moderate ASD (P = 0.047). Moreover, in terms of platelet functions, the elongation in collagen-ADP and collagen-EPI closure times were significantly higher for the ASD group (P = 0.044). These results may suggest an impairment in platelet functions rather than in platelet morphology for children with ASD. Considering these results, further investigation of thrombocyte functions in the ASD may lead to a better understanding of the pathogenesis of ASD and to the development of our limited knowledge of this disorder. Autism Res 2019, 12: 1069-1076. © 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Serotonin is a chemical that is found in brain as wells as in blood cells that function in blood clotting in the human body. There are problems related to serotonin in brains of people who have autism. Thus, blood clotting cells may also be affected in people who have autism. In this study, we compare blood clotting functions of children with autism with that of healthy controls. |
Databáze: | OpenAIRE |
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