Diverse roles of WDR5-RbBP5-ASH2L-DPY30 (WRAD) complex in the functions of the SET1 histone methyltransferase family
| Autor: | Aamir Ali, Shweta Tyagi |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Methylation General Biochemistry Genetics and Molecular Biology Histones 03 medical and health sciences 0302 clinical medicine Histone methylation Humans WDR5 Nuclear protein Regulation of gene expression Genetics biology WD Repeat-Containing Protein 5 Intracellular Signaling Peptides and Proteins Nuclear Proteins Histone-Lysine N-Methyltransferase General Medicine DNA-Binding Proteins 030104 developmental biology Histone Gene Expression Regulation Multiprotein Complexes Histone methyltransferase Histone Methyltransferases biology.protein General Agricultural and Biological Sciences 030217 neurology & neurosurgery Transcription Factors |
| Zdroj: | Journal of Biosciences. 42:155-159 |
| ISSN: | 0973-7138 0250-5991 |
| Popis: | WD repeat containing protein 5 (WDR5), Retinoblastoma Binding Protein 5 (RbBP5), Absent-Small-Homeotic-2- Like protein (ASH2L), and Dumpy-30 (Dpy30) have been reported to be the integral and shared components of all the SET1 family of histone 3 lysine 4 histone methyltransferase (HMT) complexes. Collectively called the WRAD complex, these proteins are pivotal to the HMT activity of the SET1 complexes. Recent reports highlight the novel non-canonical functions of WRAD in cellular processes other than its well-studied role in histone methylation and gene expression. In this review, we examine the diversity in emerging transcription-independent functions of WRAD. |
| Databáze: | OpenAIRE |
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