Oxycodone versus fentanyl for intravenous patient-controlled analgesia after laparoscopic supracervical hysterectomy: A prospective, randomized, double-blind study
| Autor: | Jin Hun Chung, Kyung Taek Jung, Jeong Seok Lee, Hea Rim Chun, Su Yeon Park, Aeli Ryu, Nan Seol Kim, Kyou Sik Kang, Ho Soon Chung, Seong Taek Mun |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
medicine.medical_specialty medicine.medical_treatment Hysterectomy oxycodone law.invention Fentanyl 03 medical and health sciences 0302 clinical medicine Randomized controlled trial Double-Blind Method 030202 anesthesiology law medicine Humans Prospective Studies Laparoscopy Prospective cohort study Infusions Intravenous Pain Postoperative medicine.diagnostic_test business.industry Analgesia Patient-Controlled General Medicine Clinical Trial/Experimental Study Middle Aged Surgery Analgesics Opioid Opioid Anesthesia Female business postoperative pain Oxycodone 030217 neurology & neurosurgery medicine.drug Intravenous Patient-Controlled Analgesia Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 |
| Popis: | Background: Oxycodone, a semisynthetic thebaine derivative opioid, is widely used for the relief of moderate to severe pain. The aim of this study was to compare the efficacy and side effects of oxycodone and fentanyl in the management of postoperative pain by intravenous patient-controlled analgesia (IV-PCA) in patients who underwent laparoscopic supracervical hysterectomy (LSH). Methods: The 127 patients were randomized to postoperative pain treatment with either oxycodone (n = 64, group O) or fentanyl group (n = 63, group F). Patients received 7.5 mg oxycodone or 100 μg fentanyl with 30-mg ketorolac at the end of anesthesia followed by IV-PCA (potency ratio 75:1) for 48 hours postoperatively. A blinded observer assessed postoperative pain based on the numerical rating scale (NRS), infused PCA dose, patient satisfaction, sedation level, and side effects. Results: Accumulated IV-PCA consumption in group O was less (63.5 ± 23.9 mL) than in group F (85.3 ± 2.41 mL) during the first 48 hours postoperatively (P = 0.012). The NRS score of group O was significantly lower than that of group F at 4 and 8 hours postoperatively (P |
| Databáze: | OpenAIRE |
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