Oral administration of γ-aminobutyric acid and γ-oryzanol prevents stress-induced hypoadiponectinemia
| Autor: | Hiroyuki Maehara, Kazuyuki Ohara, Masatoshi Hori, Hideki Ushio, Asako Uchida, Shigeharu Kanemoto, Yuka Kiyotani, Reiko Nagasaka |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Restraint Physical medicine.medical_specialty Administration Oral Pharmaceutical Science Type 2 diabetes Biology Aminobutyric acid Mice Insulin resistance Stress Physiological Oral administration Internal medicine Drug Discovery medicine Animals Humans Chronic stress gamma-Aminobutyric Acid Metabolic Syndrome Pharmacology Phenylpropionates Adiponectin Plant Extracts food and beverages Oryza medicine.disease Mice Inbred C57BL Endocrinology Complementary and alternative medicine Molecular Medicine Brown rice Anti-Obesity Agents Metabolic syndrome Phytotherapy |
| Zdroj: | Phytomedicine. 18:655-660 |
| ISSN: | 0944-7113 |
| DOI: | 10.1016/j.phymed.2011.01.003 |
| Popis: | Metabolic syndrome is a cluster of risk factors including insulin resistance and type 2 diabetes and is found to associate partly with chronic stress at work in human. Adiponectin circulates in mammal blood mainly as a low molecular weight (LMW) trimer, hexamer, and a high molecular weight (HMW) multimers. Low circulating levels of adiponectin are related to metabolic syndrome. We have then investigated the influence of immobilization stress on plasma adiponectin concentrations in mice. Relative LMW and HMW adiponectin levels were markedly reduced by immobilization stress (0.66±0.07 and 0.59±0.06 after 102 h, respectively), significantly different from the control values (p |
| Databáze: | OpenAIRE |
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