Difference in mitochondrial gene expression in granulosa cells between recombinant FSH and hMG cycles under in vitro fertilization and transfer
| Autor: | Yoko Yoshida, Natsuho Saito, Yoko Higuchi, Mika Kamada, Atsushi Hayashi, Yoshiki Yamashita, Sachiko Kawabe, Yoshito Terai, Hikaru Yamamoto, Masahide Ohmichi, Yoshihiro J. Ono |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
endocrine system
education.field_of_study medicine.medical_specialty Mitochondrial DNA In vitro fertilisation biology medicine.drug_class Granulosa cell medicine.medical_treatment Population Embryo Cell Biology Mitochondrion Endocrinology Reproductive Medicine Internal medicine HMG-CoA reductase medicine biology.protein Original Article Gonadotropin education |
| Popis: | Examination of the mitochondrial mRNA expression in granulosa cells from an unspecified population of infertile patients to evaluate whether recombinant follicle stimulating hormone (recFSH) is more effective in producing higher quality embryo rates compared with human menopausal gonadotropin (hMG).Thirty-nine patients who underwent the in vitro fertilization and embryo transfer program were retrospectively examined. Patients were administered recFSH (The high-quality embryo rate in the hMG cycle was higher than in the recFSH cycle, and the total dose of hMG showed a positive correlation with the expression level of mitochondrial genes in granulosa cells. Moreover, mitochondria mRNA expression was higher in the hMG cycle than in the recFSH cycle.Compared with recFSH, hMG induces a higher mitochondrial gene expression ratio in granulosa cells at the time of oocyte retrieval and, therefore, may lead to higher quality embryo rates. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|