Synthesis and properties of star oligo/poly(trimethylene carbonate)s with cholic acid moieties as cores
| Autor: | Si-Xue Cheng, Song-Lin Li, Tao Zou, Zhao-Yu Hu, Ren-Xi Zhuo |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Materials science
Cell Survival Polymers Biomedical Engineering Biophysics Bioengineering Biocompatible Materials Ring-opening polymerization Biomaterials Dioxanes chemistry.chemical_compound Polymer chemistry Animals Fourier transform infrared spectroscopy Cells Cultured Drug Carriers Cholic acid Water Nuclear magnetic resonance spectroscopy Fibroblasts Biodegradable polymer Microspheres Monomer Polymerization chemistry Prednisone Trimethylene carbonate |
| Zdroj: | Journal of biomaterials science. Polymer edition. 18(5) |
| ISSN: | 0920-5063 |
| Popis: | Star oligo/poly(trimethylene carbonate)s with cholic acid moieties as cores were synthesized by ring-opening polymerization of trimethylene carbonate (TMC) initiated by cholic acid with hydroxyl groups. The molecular weights of the star oligomers/polymers were controlled by adjusting the feed ratio of the initiator cholic acid to the monomer TMC. The star oligo/poly(trimethylene carbonate)s were characterized by Fourier transform infrared spectroscopy (FT-IR), (1)H nuclear magnetic resonance spectroscopy ((1)H-NMR) and combined size-exclusion chromatography and multiangle laser light scattering (SEC-MALLS) analysis. The water contact angles of the star oligo/poly(trimethylene carbonate)s were measured. Using 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, the star oligo/poly(trimethylene carbonate) was proved to have a low cytotoxicity. A microsphere drug-delivery system based on a star polymer was fabricated and its in vitro drug release property was studied. |
| Databáze: | OpenAIRE |
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