NONO and tumorigenesis: More than splicing
| Autor: | Bo Peng, Wei Xiong, Lin Zhang, Lanqin Cao, Neng Ling, Tanggang Deng, Peifu Feng, Ling Li, Yan Liu, Mao Ye, Lei Zhang, Siyuan Qiu |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
DNA Repair DNA repair Carcinogenesis RNA Splicing Reviews Apoptosis Review Biology medicine.disease_cause 03 medical and health sciences splicing 0302 clinical medicine Cell Movement Neoplasms Transcriptional regulation medicine Humans Nuclear protein Cell Proliferation Regulation of gene expression DBHS Cell growth RNA-Binding Proteins Cell Biology DNA-Binding Proteins Gene Expression Regulation Neoplastic Biomarker tumorigenesis 030104 developmental biology 030220 oncology & carcinogenesis RNA splicing Cancer research Molecular Medicine NONO |
| Zdroj: | Journal of Cellular and Molecular Medicine |
| ISSN: | 1582-4934 |
| Popis: | The non‐POU domain‐containing octamer‐binding protein NONO/p54nrb, which belongs to the Drosophila behaviour/human splicing (DBHS) family, is a multifunctional nuclear protein rarely functioning alone. Emerging solid evidences showed that NONO engages in almost every step of gene regulation, including but not limited to mRNA splicing, DNA unwinding, transcriptional regulation, nuclear retention of defective RNA and DNA repair. NONO is involved in many biological processes including cell proliferation, apoptosis, migration and DNA damage repair. Dysregulation of NONO has been found in many types of cancer. In this review, we summarize the current and fast‐growing knowledge about the regulation of NONO, its biological function and implications in tumorigenesis and cancer progression. Overall, significant findings about the roles of NONO have been made, which might make NONO to be a new biomarker or/and a possible therapeutic target for cancers. |
| Databáze: | OpenAIRE |
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