Possible reasons for different pattern disappearance of thyroglobulin and thyroid peroxidase autoantibodies in patients with differentiated thyroid carcinoma following total thyroidectomy and iodine-131 ablation
| Autor: | Agathocles Tsatsoulis, V. Liakos, P. Kaldrimides, E. Vassiliou, Dimitrios Thomas, F. Hatzimarkou |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Adolescent Thyroidectomy Endocrinology Diabetes and Metabolism medicine.medical_treatment Thyroid Neoplasms/immunology/mortality/pathology/*surgery Follicular cell Gastroenterology Iodide Peroxidase Thyroglobulin Thyroid carcinoma Iodine Radioisotopes Endocrinology Autoantibodies/biosynthesis/*blood Thyroid peroxidase Internal medicine medicine Humans Thyroid Neoplasms Child Thyroglobulin/*immunology Survival rate Aged Autoantibodies Retrospective Studies biology business.industry Thyroid Middle Aged Anti-thyroid autoantibodies Survival Rate medicine.anatomical_structure Iodine Radioisotopes/*therapeutic use biology.protein Female Iodide Peroxidase/*immunology business Follow-Up Studies |
| Zdroj: | Journal of endocrinological investigation. 30(3) |
| ISSN: | 1720-8386 |
| Popis: | The purpose of this study was to reveal some possible factors for the differences between the pattern of disappearance of thyroglobulin autoantibodies (anti-Tg) and thyroid peroxidase autoantibodies (anti-TPO) in patients with differentiated thyroid carcinoma following thyroidectomy and iodine-131 ablation. Patients with a history of follicular cell derived cancer (papillary, follicular, both papillary and follicular, Hurthle cell) and high pre-operative titers of anti-TPO and/or anti-Tg autoantibodies were retrospectively studied. Thyroglobulin (Tg) levels were measured using radio-immunometric assay (RIA). Anti-Tg and anti-TPO levels during the first 6 yr' follow-up were measured by passive agglutination, during the following 10 yr by ELISA method and during the last 2 yr by chemiluminescence assay. A statistically significant difference was observed between median time (72 months) of disappearance of anti-TPO and median time (39 months) of disappearance of anti-Tg in patients with complete ablation of thyroid tissue, following iodine-131 administration (p=0.0395, Logrank statistic=4.24, Kaplan-Meier method). A statistically significant difference was observed between median time (106 months) of disappearance of anti-TPO and median time (33 months) of disappearance of anti-Tg in patients >45 yr of age (p=0.034) and between median time (111 months) of disappearance of anti-TPO and median time (41 months) of disappearance of anti-Tg in patients with tumor size |
| Databáze: | OpenAIRE |
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