Splenectomy for hemocytopenia in systemic lupus erythematosus. A controlled appraisal
| Autor: | Mucia Alger, Santiago J. Rivero, Donato Alarcón-Segovia |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Hemolytic anemia
Vasculitis medicine.medical_specialty Anemia Hemolytic Medical treatment business.industry medicine.medical_treatment Significant difference Splenectomy medicine.disease Thrombocytopenic purpura Gastroenterology Thrombocytopenia Surgery Equivalent control Internal medicine Internal Medicine Medicine Humans Lupus Erythematosus Systemic In patient business Cutaneous Vasculitis |
| Zdroj: | Archives of internal medicine. 139(7) |
| ISSN: | 0003-9926 |
| Popis: | We compared 15 patients with systemic lupus erythematosus (SLE) treated with splenectomy for thrombocytopenic purpura and/or hemolytic anemia to 15 similar SLE patients treated only medically. There was no significant difference between the splenectomized and the nonsplenectomized patients when their entire course, as well as the presplenectomy and postsplenectomy or their equivalent control periods, were compared by means of an overall severity index. Splenectomized patients, however, had a significantly higher frequency of cutaneous vasculitis after splenectomy than in their own presplenectomy period and a significantly higher frequency of cutaneous vasculitis than the nonsplenectomized patients. Serious infections were more frequent in the postsplenectomy period than in an equivalent period in the nonsplenectomized patients. Splenectomy produced only short-term benefit in the management of hemocytopenic episodes in SLE and seems only warranted as an emergency procedure in patients unresponsive to medical treatment. ( Arch Intern Med 139:773-776, 1979) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|