Measurement of spinal cord atrophy using phase sensitive inversion recovery (PSIR) imaging in motor neuron disease
| Autor: | Catherine Lomen-Hoerth, Antje Bischof, William A. Stern, Howard J. Rosen, Bruce L. Miller, Roland G. Henry, Nicholas T. Olney, Nico Papinutto, Eduardo Caverzasi |
|---|---|
| Přispěvatelé: | Paul, Friedemann |
| Rok vydání: | 2018 |
| Předmět: |
Central Nervous System
Male Pathology Image Processing Neurodegenerative Pathology and Laboratory Medicine Nervous System 030218 nuclear medicine & medical imaging Diagnostic Radiology Motor Neuron Diseases 0302 clinical medicine Computer-Assisted Animal Cells Image Processing Computer-Assisted Medicine and Health Sciences Medicine Amyotrophic lateral sclerosis Gray Matter Musculoskeletal System Primary Lateral Sclerosis Neurons Motor Neurons Multidisciplinary Radiology and Imaging Neurodegenerative Diseases Middle Aged Magnetic Resonance Imaging White Matter 3. Good health Arms medicine.anatomical_structure Neurology Spinal Cord Frontotemporal Dementia Neurological Female Anatomy Cellular Types Research Article Adult medicine.medical_specialty Cord Imaging Techniques General Science & Technology Science Research and Analysis Methods Lower motor neuron White matter 03 medical and health sciences Atrophy Signs and Symptoms Rare Diseases Diagnostic Medicine Clinical Research MD Multidisciplinary Humans Motor Neuron Disease Aged business.industry Amyotrophic Lateral Sclerosis Neurosciences Biology and Life Sciences Cell Biology Motor neuron medicine.disease Spinal cord Brain Disorders Neuroanatomy Cellular Neuroscience Body Limbs ALS business 030217 neurology & neurosurgery Neuroscience |
| Zdroj: | PloS one, vol 13, iss 11 PLoS ONE Olney, Nicholas T; Bischof, Antje; Rosen, Howard; Caverzasi, Eduardo; Stern, William A; Lomen-Hoerth, Catherine; et al.(2018). Measurement of spinal cord atrophy using phase sensitive inversion recovery (PSIR) imaging in motor neuron disease. PLOS ONE, 13(11), e0208255. doi: 10.1371/journal.pone.0208255. UCSF: Retrieved from: http://www.escholarship.org/uc/item/3d49z721 PLoS ONE, Vol 13, Iss 11, p e0208255 (2018) |
| Popis: | Author(s): Olney, Nicholas T; Bischof, Antje; Rosen, Howard; Caverzasi, Eduardo; Stern, William A; Lomen-Hoerth, Catherine; Miller, Bruce L; Henry, Roland G; Papinutto, Nico | Abstract: BackgroundThe spectrum of motor neuron disease (MND) includes numerous phenotypes with various life expectancies. The degree of upper and lower motor neuron involvement can impact prognosis. Phase sensitive inversion recovery (PSIR) imaging has been shown to detect in vivo gray matter (GM) and white matter (WM) atrophy in the spinal cord of other patient populations but has not been explored in MND.MethodsIn this study, total cord, WM and GM areas of ten patients with a diagnosis within the MND spectrum were compared to those of ten healthy controls (HC). Patients' diagnosis included amyotrophic lateral sclerosis (ALS), primary lateral sclerosis, primary muscular atrophy, facial onset sensory and motor neuronopathy and ALS-Frontotemporal dementia. Axial 2D PSIR images were acquired at four cervical disc levels (C2-C3, C3-C4, C5-C6 and C7-T1) with a short acquisition time (2 minutes) protocol. Total cross-sectional areas (TCA), GM and WM areas were measured using a combination of highly reliable manual and semi-automated methods. Cord areas in MND patients were compared with HC using linear regression analyses adjusted for age and sex. Correlation of WM and GM areas in MND patients was explored to gain insights into underlying atrophy patterns.ResultsMND patients as a group had significantly smaller cervical cord GM area compared to HC at all four levels (C2-C3: p = .009; C3-C4: p = .001; C5-C6: p = .006; C7-T1: p = .002). WM area at C5-C6 level was significantly smaller (p = .001). TCA was significantly smaller at C3-C4 (p = .018) and C5-C6 (p = .002). No significant GM and WM atrophy was detected in the two patients with predominantly bulbar phenotype. Concomitant GM and WM atrophy was detected in solely upper or lower motor neuron level phenotypes. There was a significant correlation between GM and WM areas at all four levels in this diverse population of MND.ConclusionSpinal cord GM and WM atrophy can be detected in vivo in patients within the MND spectrum using a short acquisition time 2D PSIR imaging protocol. PSIR imaging shows promise as a method for quantifying spinal cord involvement and thus may be useful for diagnosis, prognosis and for monitoring disease progression. |
| Databáze: | OpenAIRE |
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