Dynapenia could predict chemotherapy-induced dose-limiting neurotoxicity in digestive cancer patients

Autor:	Barbara Tailliere, Damien Botsen, Florian Slimano, Johanna Moreau, Yohann Renard, Coralie Barbe, Mathilde Brasseur, Camille Mazza, Marine Perrier, Marie-Amélie Ordan, Eric Bertin, Olivier Bouché
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Adult Male Cancer Research medicine.medical_specialty Sarcopenia medicine.medical_treatment Kaplan-Meier Estimate Gastroenterology lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine FOLFOX Surgical oncology Internal medicine Antineoplastic agents Genetics medicine Humans Prospective Studies 030212 general & internal medicine Dose-limiting toxicity Muscle Skeletal Prospective cohort study Aged Chemotherapy Muscle Weakness Hand Strength business.industry Muscle strength Stomach Middle Aged lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Discontinuation Oxaliplatin Regimen medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Digestive system neoplasms Female business Dynapenia Research Article medicine.drug
Zdroj:	BMC Cancer, Vol 18, Iss 1, Pp 1-9 (2018) BMC Cancer
ISSN:	1471-2407
DOI:	10.1186/s12885-018-4860-1
Popis:	Background FIGHTDIGO study showed the feasibility and acceptability of handgrip strength (HGS) measure in routine in 201 consecutive patients with digestive cancer treated with ambulatory chemotherapy. The present study focuses on the second aim of FIGHTDIGO study: the relationships between pre-therapeutic dynapenia and chemotherapy-induced Dose-Limiting Toxicities (DLT). Methods In this ancillary prospective study, DLT were analyzed in a sub-group of 45 chemotherapy-naive patients. Two bilateral consecutive measures of HGS were performed with a Jamar dynamometer before the first cycle of chemotherapy. Dynapenia was defined as HGS
Databáze:	OpenAIRE
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