Cystic nephroma with renal vein thrombus in a child with DICER1 mutation: A case report
| Autor: | Erin K Barr, Viviane Mamlok, Matthew D. Timberlake, Erin Somang Choi, Cynthia Smith |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Vena cava biology business.industry Cystic nephroma medicine.medical_treatment Nephroma tumor thrombus thrombectomy DICER1 mutation cancer predisposition syndrome medicine.disease biology.organism_classification lcsh:Diseases of the genitourinary system. Urology lcsh:RC870-923 Nephrectomy Tumor thrombus Pediatrics Urology Pathology Surgery medicine cardiovascular system nephroma tumor thrombus thrombectomy dicer1 mutation cancer predisposition syndrome Nephroma Radiology cardiovascular diseases Renal vein Thrombus business |
| Zdroj: | Pediatric Urology Case Reports, Vol 7, Iss 6, Pp 149-154 (2020) Pediatric Urology Case Reports; Vol 7, No 6 (2020): Nov-Dec; 149-154 |
| ISSN: | 2148-2969 |
| Popis: | Venous tumor thrombus is a known manifestation of Wilms’ tumors in a minority of cases but has not been previously described in association with cystic nephroma. We report an original case of a histologically-benign cystic nephroma presenting with venous tumor thrombus extending to the inferior vena cava. The tumor thrombus was not detected by preoperative Doppler ultrasound. The patient was successfully treated with radical nephrectomy, tumor thrombectomy, and IVC closure. Postoperatively, the patient underwent genetic testing which revealed a DICER1 mutation—known to predispose affected individuals to a variety of benign and malignant tumors—and requires intensive surveillance for associated conditions. |
| Databáze: | OpenAIRE |
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