Intratumoral generation of 2-fluoroadenine to treat solid malignancies of the head and neck
| Autor: | Eben L. Rosenthal, Eric J. Sorscher, William B. Parker, Turang E. Behbahani |
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| Rok vydání: | 2018 |
| Předmět: |
Purine nucleoside phosphorylase
Tumor cells Gene transfer Article 03 medical and health sciences 0302 clinical medicine Transduction Genetic medicine Escherichia coli Humans Head and neck 030304 developmental biology 0303 health sciences business.industry Squamous Cell Carcinoma of Head and Neck Adenine medicine.disease Head and neck squamous-cell carcinoma Experimental strategy Clinical trial stomatognathic diseases Otorhinolaryngology Purine-Nucleoside Phosphorylase Head and Neck Neoplasms 030220 oncology & carcinogenesis Cancer research 2-fluoroadenine business |
| Zdroj: | Head Neck |
| ISSN: | 1097-0347 |
| Popis: | This report describes treatment of locoregional head and neck squamous cell carcinoma (HNSCC) by an innovative, experimental strategy involving generation of a robust anti-cancer agent (2-fluoroadenine [F-Ade]) following transduction by Escherichia coli purine nucleoside phosphorylase (PNP) in a small number of tumor cells. F-Ade works by a unique mechanism of action (ablation of RNA and protein synthesis) and confers tumor regressions of otherwise refractory HNSCC in human subjects. Clinical studies have now advanced to a pivotal (registration-directed) trial involving locoregional HNSCC, with plans to begin subject enrollment late in 2018. The present review is the first to summarize use of PNP in the context of HNSCC, and provides background regarding this emerging anti-cancer approach. |
| Databáze: | OpenAIRE |
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