An Estimation Method of the Clearance for a One-Compartment Model of a Single Bolus Intravenous Injection by a Single Sampling
| Autor: | Ikuko Funatogawa, Takashi Funatogawa |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Statistics and Probability
Metabolic Clearance Rate Sample point Models Biological Pharmacokinetics Statistics medicine Animals Humans Pharmacology (medical) Point estimation Cadralazine Compartment (pharmacokinetics) Pharmacology Volume of distribution Dose-Response Relationship Drug business.industry Sampling (statistics) Bayes Theorem Pharmaceutical Preparations Single bolus Injections Intravenous business Half-Life medicine.drug Biomedical engineering |
| Zdroj: | Journal of Biopharmaceutical Statistics. 22:43-53 |
| ISSN: | 1520-5711 1054-3406 |
| DOI: | 10.1080/10543406.2010.502983 |
| Popis: | In clinical trials, sometimes only a single drug concentration can be measured from a patient, because of the burden on the patient. From a single concentration, we cannot generally obtain point estimates of each pharmacokinetic parameter in a patient. In this article, we propose a method to estimate the clearance using a one-compartment model of a single-bolus intravenous injection from a single concentration at a sampling point between 1.5 and 2.5 half-lives. This method requires an assumed value for the volume of distribution but is robust to misspecification. This approach is illustrated by simulated concentration data and cadralazine concentration data. |
| Databáze: | OpenAIRE |
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