A quantitative real-time PCR high resolution melting (HRM) method for evaluating the O6-methylguanine-DNA-methyltransferase (MGMT) promoter methylation status in malignant gliomas is superior to conventional methylation specific PCR in predicting clinical outcome and survival in patients with malignant glioma

Autor:	Switzeny, Olivier J., Renovanz, Mirjam, Sommer, Clemens, Christmann, Markus, Giese, Alf, Kaina, Bernd
Jazyk:	angličtina
Rok vydání:	2015
Předmět:	ddc: 610 malignant glioma 610 Medical sciences Medicine MGMT neoplasms digestive system diseases high resolution melting
Zdroj:	66. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC); 20150607-20150610; Karlsruhe; DOCP 040 /20150602/
DOI:	10.3205/15dgnc438
Popis:	Objective: MGMT promoter status is an important prognostic factor in high-grade glioma patients and indispensable for decision making in neurooncological therapy. Currently, the MGMT promoter methylation is determined by methylation-specific PCR (MSP). The development of new approaches to improving [for full text, please go to the a.m. URL] 66. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ac1e1abf76cb174335a383f662d39f Zobrazit plný text záznamu