Mice selectively bred for high voluntary wheel running have larger midbrains: support for the mosaic model of brain evolution
| Autor: | Enrico L. Rezende, Sun K. Lee, Andre Obenaus, A. Radtke, Theodore Garland, Erik M. Kolb, L. Holness |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Physiology Hippocampus Aquatic Science Biology Breeding Running Midbrain Mice Mesencephalon medicine Animals Molecular Biology Ecology Evolution Behavior and Systematics Brain Mass Encephalization Brain Organ Size Biological Evolution Ventral tegmental area medicine.anatomical_structure nervous system Insect Science Forebrain Brain size Animal Science and Zoology Female House mice Neuroscience |
| Zdroj: | The Journal of experimental biology. 216(Pt 3) |
| ISSN: | 1477-9145 |
| Popis: | Increased brain size, relative to body mass, is a primary characteristic distinguishing the mammalian lineage. This greater encephalization has come with increased behavioral complexity and, accordingly, it has been suggested that selection on behavioral traits has been a significant factor leading to the evolution of larger whole-brain mass. In addition, brains may evolve in a mosaic fashion, with functional components having some freedom to evolve independently from other components, irrespective of, or in addition to, changes in size of the whole brain. We tested whether long-term selective breeding for high voluntary wheel running in laboratory house mice results in changes in brain size, and whether those changes have occurred in a concerted or mosaic fashion. We measured wet and dry brain mass via dissections and brain volume with ex vivo magnetic resonance imaging of brains that distinguished the caudate-putamen, hippocampus, midbrain, cerebellum and forebrain. Adjusting for body mass as a covariate, mice from the four replicate high-runner (HR) lines had statistically larger non-cerebellar wet and dry brain masses than those from four non-selected control lines, with no differences in cerebellum wet or dry mass or volume. Moreover, the midbrain volume in HR mice was ~13% larger ( P |
| Databáze: | OpenAIRE |
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