DEVELOPMENT, COMPUTATIONAL STUDIES AND VALIDATION OF SPECTROPHOTOMETRIC METHOD OF METFORMIN HYDROCHLORIDE IN PHARMACEUTICAL FORMULATIONS

Autor:	Yunusa Umar, Abdulla Sarief, Ahmed Abu Judeh, Omar Ashwaq, Sk Manirul Haque
Rok vydání:	2020
Předmět:	Detection limit Materials science Chromatography Computational Method development Validation General Chemistry Metformin Hydrochloride Spectrophotometer Metformin Dosage form Tablets
Zdroj:	Journal of the Chilean Chemical Society v.65 n.3 2020 SciELO Chile CONICYT Chile instacron:CONICYT
ISSN:	0717-9707
Popis:	Simple, fast, and sensitive spectrophotometric method was developed for the determination of metformin in pharmaceutical formulations. The spectrophotometric procedure was based on the oxidation of metformin with potassium permanganate in alkaline medium. The developed method was also validated according to International Conference on Harmonization guidelines parameters such as linearity, accuracy, precision, limit of detection and quantitation. Studies were conducted to investigate different parameters involved in color developments and optimized. The pure drug of metformin was extracted from a pharmaceutical dosage form. The extraction procedure was developed, and a possible reaction mechanism proposed in the manuscript. The IR spectrum of the extracted metformin was taken and compared with the simulated IR spectrum obtained from the density functional theory calculation. The vibrational assignment of the modes was done based on potential energy distribution.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56a79e16c939f5b732943046d3fba42d https://doi.org/10.4067/s0717-97072020000204895 Zobrazit plný text záznamu