Hepatitis E, Helicobacter pylori, and peptic ulcers in workers exposed to sewage: a prospective cohort study
| Autor: | Silvia Hilfiker, Philipp Hotz, Susanne Widmeier, Stefan Jeggli, Alois Tschopp, Robert Steffen, Helen Joller |
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| Přispěvatelé: | University of Zurich, Hotz, Philipp |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Peptic Ulcer Adolescent Peptic 610 Medicine & health medicine.disease_cause Helicobacter Infections Young Adult Hepatitis E virus Internal medicine Occupational Exposure Medicine Humans Hepatitis Antibodies Seroconversion Prospective cohort study Aged biology Helicobacter pylori Sewage business.industry Incidence (epidemiology) Protective Devices Public Health Environmental and Occupational Health 10060 Epidemiology Biostatistics and Prevention Institute (EBPI) 2739 Public Health Environmental and Occupational Health Middle Aged biology.organism_classification Hepatitis E medicine.disease Antibodies Bacterial Occupational Diseases Immunology Female business Epidemiologic Methods Switzerland Cohort study |
| Popis: | Background: Workers exposed to sewage may have an increased risk of infection by Helicobacter pylori and hepatitis E virus (HEV). Objectives: To assess the incidence of clinical hepatitis E and peptic ulcers and the seroconversion rate of antibodies to H pylori and HEV in workers with and without sewage exposure. Methods: 332 workers exposed to sewage and a control group of 446 municipal manual workers (61% participation rate) entered a prospective cohort study with clinical examination and determination of antibodies to H pylori and HEV (immunoglobulins G and A or G and M, respectively). Survival curves were examined with log rank tests and Cox regressions. Travelling to endemic areas, socioeconomic level, age, country of childhood, number of siblings, and personal protective equipment were considered as the main confounding factors. Results: Incidence of clinical hepatitis E was not increased in sewage workers. One peptic ulcer and three eradications were recorded in sewage workers compared with no peptic ulcers and 12 eradications in control workers. Incidence rates of approximately 0.01, 0.10, and 0.15 seroconversion/person-year for hepatitis E, H pylori IgG and H pylori IgA, respectively, were found in both exposed and non-exposed workers. Survival curves did not show an increased risk in sewage workers and no association with any exposure indicator was found. Sensitivity analyses did not alter these results. Conclusions: Sewage does not appear to be a source of occupational infection by H pylori or HEV in trained sewage workers with personal protective equipment working in a region with good sanitation. |
| Databáze: | OpenAIRE |
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