Interactions of Neisseria gonorrhoeae with Mature Human Macrophage Opacity Proteins Influence Production of Proinflammatory Cytokines
| Autor: | Peter J. Watt, Benjamin L. Makepeace, Myron Christodoulides, John E. Heckels |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_treatment
Chemokine CXCL1 Immunology Biology Microbiology Proinflammatory cytokine Pelvic inflammatory disease medicine Macrophage Humans Secretion Interleukin 8 Chemokine CCL4 Growth Substances Macrophage inflammatory protein Chemokine CCL5 Chemokine CCL3 Host Response and Inflammation Antigens Bacterial Chemotactic Factors Interleukin-6 Tumor Necrosis Factor-alpha Macrophages Interleukin-8 Macrophage Inflammatory Proteins Neisseria gonorrhoeae Infectious Diseases Cytokine Cytokines Intercellular Signaling Peptides and Proteins Parasitology Tumor necrosis factor alpha Chemokines CXC |
| Popis: | The pathological features of ascending gonococcal infection suggest that proinflammatory mediators secreted by tissue-resident macrophages are important components of the host response. Challenge of fully differentiated, mature macrophages with variants ofNeisseria gonorrhoeaestrain P9 or purified bacterial surface components (pili, lipooligosaccharide, and outer membrane vesicles) induced the secretion of interleukin 6 (IL-6), tumor necrosis factor alpha, growth-related protein α, macrophage inflammatory protein 1α (MIP-1α), and RANTES cytokines but had no effect on IL-8 production. No secretion of IL-1β, epithelial-derived neutrophil attractant 78, granulocyte-macrophage colony-stimulating factor, IL-10, or IL-12 cytokines was observed. Notably, the P9-Opabprotein, in comparison to P9-Opaa, increased the association of gonococci with macrophages and elevated the secretion of cytokines. Thus, variation in Opa protein expression by the gonococcus may be a determining factor in the severity of pelvic inflammatory disease. |
| Databáze: | OpenAIRE |
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