Predisposition to nasal bleeding in horses
| Autor: | R. Alrafy, T. T. Glazko, T. A. Erkenov, V. I. Glazko |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
Genetics education.field_of_study Inverted repeat 010604 marine biology & hydrobiology Population Horse virus diseases Genetic relationship Biology 01 natural sciences Breed Psychiatry and Mental health Neuropsychology and Physiological Psychology Mutation (genetic algorithm) Microsatellite General Earth and Planetary Sciences education Genotyping geographic locations 010606 plant biology & botany General Environmental Science |
| Zdroj: | Rossiiskaia selskokhoziaistvennaia nauka. :49-53 |
| ISSN: | 2500-2627 |
| Popis: | The predisposition of horses to nasal bleeding significantly affects their performance and requires special control especially in the breeding work aimed at improving the breed, improving its working qualities. One of the causes of such bleeding is spontaneous nucleotide substitutions in the D'-D3 domain of von Willebrand factor. In this paper, the presence and distribution of mutations in the domain D'-D3 of this factor is analyzed (c.2826 AC in exon 22, leading to the replacement of lysine by asparagine) in Russian horse breeds (Russian Trotter, Russian Saddle horse, Russian Heavyweight, Altai, Karachai horse breeds).The highest frequency of this replacement was found in the Russian Trotter and Russian Heavyweight. To clarify the possible relationship of the spread of this mutation with the population-genetic relationship between horse breeds on 26 fragments of genomic DNA, flanked by inverted repeats sections of microsatellites (GA)9C, (AG)9C and (GAG)6C (Inter Simple Sequence Repeats ISSR-PCR markers) polylocus genotyping was performed, genetic distances were calculated and corresponding dendrograms were constructed. It turned out that the prevalence of the detected mutation is not related to the population-genetic proximity of breeds. However, given the fact that historically in the formation of the Russian Trotter and Russian Heavyweight took part Orel horse breed, it is possible that the high frequency of this mutation in the Russian Trotter and the Russian Heavyweight may be due to its presence in the group of Oryol horses that are the source for these breeds. |
| Databáze: | OpenAIRE |
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