Prognostic significance of immunohistochemical classification of diffuse large B-cell lymphoma
| Autor: | Güner Hayri Özsan, Inci Alacacioglu, Aydanur Kargi, Sermin Özkal, Özden Pişkin, Nurhilal Turgut, Mehmet Ali Özcan, Fatih Demirkan, Bülent Ündar |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Adolescent Protein Array Analysis Gastroenterology Disease-Free Survival Immunoenzyme Techniques Young Adult immune system diseases hemic and lymphatic diseases Internal medicine Medicine Humans Immunoperoxidase Staining Clinical significance Aged Retrospective Studies Aged 80 and over business.industry Event free survival Germinal center Hematology Middle Aged medicine.disease Prognosis Immunohistochemistry Lymphoma Survival Rate Female Lymphoma Large B-Cell Diffuse business Diffuse large B-cell lymphoma |
| Popis: | To evaluate the clinical significance of immunoperoxidase staining for CD10, bcl-6, mum-1 and bcl-2 to subdivide DLBCL into prognostic subgroups, we analysed 50 DLBCL cases using immunohistochemical methods.Fifty DLBCL patients were evaluated retrospectively. The expression of CD10 was associated with better OS (p=0.04) whereas expression of mum-1 was associated with worse OS (p=0.009). There were no significance of OS in case of expression of bcl-6 (p=0.05) and bcl-2 (p=0.3). They were subclassified using CD10, mum-1, bcl-6 as germinal center B-cell like (GCB) lymphoma (30%) and non-GCB lymphoma (70%). The OS and EFS (event free survival) were longer in GCB group (p=0.002) and 5-year OS for GCB group was 92% compared with only 44% for the non-GCB group (p=0.02). The OS of the GCB group also was longer compared to that of the non-GCB group in low IPI subgroup (p=0.01).The existence of survival differences between GCB a non-GCB group also in the patients with low IPI score, showed the importance of prognostic classification in the risk-adaptive treatment approaches. The classification as GCB and non-GCB based immunostains may enable to define more accurate prognostic groups in DLBCL. |
| Databáze: | OpenAIRE |
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