Hepatic steatosis and peroxisomal fatty acid beta-oxidation
| Autor: | Sailesh Surapureddi, Mustapha Cherkaoui-Malki, Joseph Vamecq, Hammam I El-Hajj, Pierre Andreoletti |
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| Rok vydání: | 2011 |
| Předmět: |
Pharmacology
chemistry.chemical_classification Clinical Biochemistry Fatty Acids Liver Neoplasms Fatty acid Peroxisome proliferator-activated receptor Lipid metabolism Peroxisome Biology Fatty acid beta-oxidation medicine.disease Fatty Liver chemistry Biochemistry medicine Peroxisomes Animals Humans PPAR alpha Peroxisome proliferator-activated receptor alpha Steatosis Flux (metabolism) Oxidation-Reduction |
| Zdroj: | Current drug metabolism. 13(10) |
| ISSN: | 1875-5453 |
| Popis: | Three subhepatocellular compartments concur for fatty acids degradation including ω-oxidation in endoplasmic reticulum and β-oxidation in both mitochondria and peroxisomes. Deficits affecting the peroxisomal physiology may be associated with multiple metabolic disturbances. Nowadays, a growing body of evidence underlines the key role of peroxisomal β-oxidation in the sensing of lipid metabolism through the production/degradation of some essential metabolites. Lessons from several mice models strengthen the link between fatty acid β-oxidation in peroxisomes and the nuclear hormone receptor Peroxisome Proliferator-Activated Receptor (PPAR)-α with an additional level of coregualtor complexity, which couples regulation of body energetic balance and hepatic caloric flux to functional peroxisome status. Here, we review key determinants of disrupted peroxisomal β-oxidation pathway, which in liver promotes hepatic steatosis and hepatocarcinogenesis. |
| Databáze: | OpenAIRE |
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