Emergence of New Virulent Neisseria meningitidis Serogroup C Sequence Type 11 Isolates in France
| Autor: | Isabelle Parent du Chatelet, Eva Hong, Muhamed-Kheir Taha, Jean-Michel Alonso, Daniel Lévy-Bruhl, Marek Szatanik, Dario Giorgini, Ala-Eddine Deghmane, Corinne Ruckly |
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| Přispěvatelé: | Centre National de Référence des Méningocoques et Haemophilus influenzae - National Reference Center Meningococci and Haemophilus influenzae (CNR), Institut Pasteur [Paris], Neisseria, Institut de Veille Sanitaire (INVS), Infections Bactériennes Invasives, Institut Pasteur [Paris] (IP) |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Neisseria meningitidis
medicine.disease_cause MESH: Meningococcal Infections Disease Outbreaks Mice Immunology and Allergy MESH: Animals MESH: Disease Outbreaks 0303 health sciences biology Incidence (epidemiology) Transferrin MESH: Meningitis Meningococcal MESH: Enzyme-Linked Immunosorbent Assay Phenotype 3. Good health Vaccination Infectious Diseases Bacterial Vaccines Neisseriaceae France MESH: Transferrin MESH: Mice Transgenic Virulence Enzyme-Linked Immunosorbent Assay Mice Transgenic Meningitis Meningococcal Meningococcal disease MESH: Phenotype MESH: Neisseria meningitidis Microbiology Colony-Forming Units Assay 03 medical and health sciences medicine Animals Humans MESH: Colony-Forming Units Assay MESH: Mice 030304 developmental biology MESH: Humans 030306 microbiology biology.organism_classification medicine.disease Virology [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology Meningococcal Infections MESH: France Disease Models Animal [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie MESH: Disease Models Animal Bacteria MESH: Bacterial Vaccines |
| Zdroj: | Journal of Infectious Diseases Journal of Infectious Diseases, Oxford University Press (OUP), 2010, 202 (2), pp.247-250. ⟨10.1086/653583⟩ Journal of Infectious Diseases, 2010, 202 (2), pp.247-250. ⟨10.1086/653583⟩ |
| ISSN: | 0022-1899 1537-6613 |
| DOI: | 10.1086/653583⟩ |
| Popis: | International audience; In France, there have been variations in the incidence of invasive meningococcal infection due to serogroup C isolates. Infection peaks were observed in 1992 and 2003 that involved isolates of phenotypes C:2a:P1.5,2 and/or C:2a:P1.5, which belong to the sequence type 11 (ST-11) clonal complex. We report an emergence of isolates belonging to the ST-11 clonal complex since 2003. These isolates displayed a new phenotype, C:2a:P1.7,1, caused infections that occurred as clusters, and were associated with increased infection severity and high virulence in mice. These isolates may be responsible for a peak in the incidence of serogroup C meningococcal infection in France, for which there is no routine vaccination to date. |
| Databáze: | OpenAIRE |
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