An efficient fluoride-mediated O-arylation of sterically hindered halophenols with silylaryl triflates under mild reaction conditions
| Autor: | Gleison A. Casagrande, Karimi S. Gebara, Cristiano Raminelli |
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| Rok vydání: | 2011 |
| Předmět: |
Steric effects
Functionalized diaryl ethers Trimethylsilyl Aryl Organic Chemistry Ether O-Arylation Aryne Medicinal chemistry Benzyne chemistry Biochemistry Solvent chemistry.chemical_compound Silylaryl triflates chemistry Drug Discovery Organic chemistry Acetonitrile Mild reaction conditions Fluoride |
| Zdroj: | Tetrahedron Letters. 52(22):2849-2852 |
| ISSN: | 0040-4039 |
| DOI: | 10.1016/j.tetlet.2011.03.124 |
| Popis: | The reaction between 2,6-dihalophenols and 2-(trimethylsilyl)aryl triflates in the presence of CsF using acetonitrile as solvent at room temperature led to the formation of functionalized diaryl ethers in very good yields. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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