HLA-DRB1 genes and the expression dynamics of HLA CIITA determine the susceptibility to T2DM
| Autor: | Rathika Chinniah, Murali Vijayan, Padma Malini Ravi, Sasiharan Pandi, Vandit Sevak, Arun Kannan, Balakrishnan Karuppiah |
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| Rok vydání: | 2020 |
| Předmět: |
musculoskeletal diseases
0301 basic medicine Adult Male medicine.medical_specialty Immunology Single-nucleotide polymorphism Human leukocyte antigen Biology Polymorphism Single Nucleotide Pathogenesis 03 medical and health sciences 0302 clinical medicine Immunophenotyping immune system diseases Internal medicine Genotype Genetics medicine Humans Genetic Predisposition to Disease Allele skin and connective tissue diseases HLA-DRB1 Nuclear Proteins Middle Aged 030104 developmental biology Endocrinology Diabetes Mellitus Type 2 Case-Control Studies Trans-Activators Female CD8 030215 immunology HLA-DRB1 Chains |
| Zdroj: | Immunogenetics. 73(4) |
| ISSN: | 1432-1211 |
| Popis: | Type 2 diabetes mellitus (T2DM) is a disease with polygenic inheritance. The expression of major histocompatibility complex class II genes are regulated by several trans-activators. We have studied the expression of HLA-DRB1, RFX, CIITA-P1, PIV transactivators, immunophenotyping of cells, SNPs in CIITA-168 (A/G) and IFN-γ + 874 (T/A) in T2DM patients and controls (n = 201 each). We observed increased frequencies of DRB1*03, DRB1*04 and DRB1*07 and decreased frequencies of DRB1*10, DRB1*14, and DRB1*15 alleles among patients. Significant up-regulations of HLA-DRB1 genes were observed in patients (p |
| Databáze: | OpenAIRE |
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