Cyclophilin A Is Overexpressed in Hepatocellular Carcinoma and Is Associated with the Cell Cycle
| Autor: | Jian Chen, Zhaohua Gong, Jiahui Wang, Fengcai Du, Xiaojuan Huang, Cheng Chi, Lixin Jiang, Hongjin Chu |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Cancer Research Carcinoma Hepatocellular Cypa 03 medical and health sciences Cyclophilin A Plasmid Cell Line Tumor medicine Humans neoplasms Cell Proliferation Neoplasm Staging biology Transition (genetics) Cell Cycle Liver Neoplasms General Medicine Transfection Cell cycle biology.organism_classification medicine.disease digestive system diseases Up-Regulation Gene Expression Regulation Neoplastic 030104 developmental biology Oncology Hepatocellular carcinoma Disease Progression Cancer research Immunohistochemistry Female |
| Zdroj: | Anticancer Research. 37 |
| ISSN: | 1791-7530 0250-7005 |
| DOI: | 10.21873/anticanres.11839 |
| Popis: | AIM To investigate the expression of cyclophilin A (CypA) in human hepatocellular carcinoma (HCC) and explore the effects of CypA on the cell cycle in HCC. MATERIALS AND METHODS CypA expression was assessed by immunohistochemistry in 48 cases of HCC tissues and paired adjacent tissues. CypA plasmid was transfected into HCC cells and the cell cycle was analyzed. RESULTS Positivity for CypA was higher in HCC tissues than in adjacent tissues (79.1% vs. 12.5%, p |
| Databáze: | OpenAIRE |
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