Fecal microbiota transplantation ameliorates gut microbiota imbalance and intestinal barrier damage in rats with stress‐induced depressive‐like behavior

Autor:	Li Lin, Lei Du, Gongying Li, Xindie Zeng, Chunmei Wang, Jian Jiang, Jingjing Rao, Ruining Xie, Yi Qiao
Rok vydání:	2021
Předmět:	medicine.medical_specialty Gut–brain axis Ileum Inflammation Gut flora Occludin digestive system 03 medical and health sciences 0302 clinical medicine Intestinal mucosa Internal medicine medicine Animals Neuroinflammation 030304 developmental biology 0303 health sciences Gastrointestinal tract biology Depression General Neuroscience Brain Fecal Microbiota Transplantation biology.organism_classification Gastrointestinal Microbiome Rats Endocrinology medicine.anatomical_structure medicine.symptom Stress Psychological 030217 neurology & neurosurgery
Zdroj:	European Journal of Neuroscience. 53:3598-3611
ISSN:	1460-9568 0953-816X
DOI:	10.1111/ejn.15192
Popis:	The gut-microbiota-brain axis is the most important complex and bidirectional pathway between the gastrointestinal tract and the central nervous system. This study investigated the potential of microbe-induced gut-to-brain signaling to modulate the effect of stress on depressive-like behavior, intestinal barrier, and neuroinflammation. Result showed that fecal microbiota transplantation increased the consumption of sucrose solutions and decreased the immobility time in forced swimming test. This treatment also increased Firmicutes and decreased Bacteroidetes and Desulfobacterota at phylum levels; reduced the loss of villi and epithelial cells; suppressed the inflammatory cell infiltration in the ileum; increased the expression of ZO-1, occludin; protected the mucosal layer function; and suppressed the high levels of inflammasomes (NLRP3, ASC, caspase-1, and IL-1β) in rat brain. In summary, fecal microbiota transplantation improves the depressive-like behavior, alters the gut microbiota imbalance, and alleviates the intestinal tract inflammation, intestinal mucosa disruption, and neuroinflammation in rats induced by chronic unpredictable mild stress.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5697a412eb8cd8e52836b1d9e3f77fa5 https://doi.org/10.1111/ejn.15192 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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