Effect of local aromatase inhibition in endometriosis using a new chick embryo chorioallantoic membrane model
| Autor: | Jean-Marie Wenger, Roberto Marci, Giorgia Poppi, Jean-Christophe Tille, Lucile Yart, Marie-Benoîte Cohen, Nicola Pluchino |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
endometriosis Chick embryo chorioallantoic membrane Short Communication anastrozole Endometriosis Short Communications Anastrozole Socio-culturale Chick Embryo ddc:616.07 anastrozole chick embryo chorioallantoic membrane endometriosis Chorioallantoic Membrane Lesion 03 medical and health sciences 0302 clinical medicine medicine Animals Humans Cyst Aromatase Cell Proliferation ddc:618 biology business.industry Aromatase Inhibitors Letrozole Embryo Cell Biology medicine.disease Chorioallantoic membrane Disease Models Animal 030104 developmental biology 030220 oncology & carcinogenesis biology.protein Cancer research Molecular Medicine chick embryo chorioallantoic membrane Female medicine.symptom business medicine.drug |
| Zdroj: | Journal of Cellular and Molecular Medicine Journal of Cellular and Molecular Medicine, Vol. 23, No 8 (2019) pp. 5808-5812 |
| ISSN: | 1582-1838 |
| Popis: | Endometriosis is an oestrogen‐dependent, inflammation‐driven gynaecologic disorder causing severe disability. Endometriosis implants are characterized by unbalanced local oestrogen metabolism leading to hyperoestrogenism and aromatase up‐regulation is one of main mechanism involved. Aromatase inhibitors such as letrozole or anastrozole use in young women are associated with severely side effects limiting their long‐term clinical use. An endometriosis‐targeted inhibition of local aromatase could be a viable alternative, although the role of the local inhibition of this enzyme is still unclear. Using a new chick embryo allantoic membrane (CAM) model incorporating xenografted human endometriosis cyst, we showed that topical treatment with anastrozole reduced lesion size, although oestrogens produced by CAM female embryo blunted this effect. Xenografted human endometriosis CAM is a new efficient model for the screening of new drugs targeting endometriosis tissue. |
| Databáze: | OpenAIRE |
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