The Cytokine and Chemokine Profiles in Rhabdomyolysis in a Patient with Gaucher Disease Type II
| Autor: | Masahiro Kikuchi, Naomi Hino-Fukuyo, Shigeru Tsuchiya, Hiroyuki Yokoyama, Kazuie Iinuma, Noriko Togashi, Keisuke Wakusawa, Kazuhiro Haginoya, T. Ohura, I. Sato, Mamiko Ishitobi |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Chemokine medicine.medical_treatment Granulocyte Rhabdomyolysis Interferon medicine Humans Gaucher Disease biology business.industry Monocyte Infant Interleukin General Medicine medicine.disease Pathophysiology medicine.anatomical_structure Cytokine Pediatrics Perinatology and Child Health Immunology biology.protein Cytokines Neurology (clinical) business medicine.drug |
| Zdroj: | Neuropediatrics. 41:39-42 |
| ISSN: | 1439-1899 0174-304X |
| Popis: | This report describes a patient with Gaucher disease type II who developed severe rhabdomy- olysis. We treated him successfully and meas- ured various cytokine and chemokine levels sequentially to elucidate the pathophysiology of rhabdomyolysis. The serum levels of interleukin- 6, − 8, − 10, granulocyte colony-stimulating fac- tor, interferon- γ , and monocyte chemoattractant protein-1 were markedly elevated in the early phase of rhabdomyolysis. These fi ndings indicate that cytokines and chemokines are related to the massive myolysis and regenerating process. A viral infection may have triggered rhabdomy- olysis through exaggerated activation of macro- phages in our patient. The profi les of cytokines and chemokines should be examined in further cases to increase our understanding of the patho- physiology of rhabdomyolysis. |
| Databáze: | OpenAIRE |
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