Myocardial performance and aortic elasticity are impaired in patients with ankylosing spondylitis

Autor:	George E. Tzelepis, I. Moyssakis, Elias Gialafos, Kyriaki A. Boki, Petros P. Sfikakis, V. Votteas, V. Vassiliou
Rok vydání:	2009
Předmět:	Adult Male medicine.medical_specialty Immunology Aortic Diseases Ventricular Function Left Rheumatology medicine.artery Internal medicine medicine Immunology and Allergy Humans In patient Spondylitis Ankylosing Spondylitis Aortic elasticity Aorta Ankylosing spondylitis business.industry Models Cardiovascular General Medicine Middle Aged medicine.disease Elasticity Surgery Early Diagnosis Echocardiography Multivariate Analysis Cardiology Linear Models Aortic stiffness Tei index Female business Compliance
Zdroj:	Scandinavian journal of rheumatology. 38(3)
ISSN:	1502-7732
Popis:	To measure aortic stiffness and global left ventricular (LV) function in patients with ankylosing spondylitis (AS) and no clinical evidence of heart disease.Fifty-seven consecutive patients with AS (54 males, three females, mean age 41.78+/-10.02 years) without clinical evidence of cardiac involvement and 78 healthy subjects (73 males, five females, mean age 39.92+/-9.11 years) underwent complete echocardiographic study. Aortic stiffness was determined non-invasively by aortic distensibility (AoD) and the global LV function was evaluated by the myocardial performance index (the Tei index).AoD in patients with AS [(2.21+/-0.24)x10(-6) cm(2) dyn(-1)] was decreased compared to controls [(2.58+/-0.19) )x10(-6) cm(2) dyn(-1), p0.01], confirming that aortic stiffness is increased in AS. The LV Tei index was significantly increased in the patient group compared to the control group (0.392+/-0.031 vs. 0.370+/-0.034, p0.01). The ejection fraction (EF) did not differ between the two groups (p0.05). In multivariate linear regression analysis, AoD was significantly associated with the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and LV isovolumic relaxation time (IVRT) whereas the LV Tei index was associated with BASDAI and the LV mass index.Patients with AS and no clinical evidence of cardiac disease have increased stiffness of the aorta and decreased global myocardial performance and both of these abnormal measurements correlate with disease activity. The abnormal Tei index may reflect an early manifestation of cardiac dysfunction in these patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::569675d194b39a6da583494e510fd1db https://pubmed.ncbi.nlm.nih.gov/19229673 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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