Superoxide production of polymorphonuclear leukocytes in surgical patients with gastric cancer
| Autor: | Seiichiroh Watabe, Tohru Nakagoe, Akimitsu Tomonaga, Masao Tomita, Tsutomu Kitamura |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Blood Bactericidal Activity animal structures Neutrophils Gastroenterology chemistry.chemical_compound Surgical oncology Stomach Neoplasms Superoxides Internal medicine medicine Humans Pathological Aged Superoxide business.industry Carcinoma Liver Neoplasms Cancer hemic and immune systems Hepatology Middle Aged medicine.disease chemistry Lymphatic Metastasis Adenocarcinoma Female Complication business Abdominal surgery |
| Zdroj: | Gastroenterologia Japonica. 21(2) |
| ISSN: | 0435-1339 |
| Popis: | Superoxide production (SOP) by polymorphonuclear leukocytes (PMNs) in 65 gastric cancer patients, who were in preoperative state and had received no medical therapy, was assayed in order to evaluate the bactericidal activity of PMNs in cancer patients, as well as to determine the correlation of SOP by PMNs with postoperative prognoses and several factors by which extent of disease and the clinical or histological character of gastric carcinoma were defined. Patients with stage II disease had a tendency to have an increased SOP by PMNs, and furthermore, as the disease progressed, the SOP by PMNs decreased with significant depression being noted in stage III and IV cases compared to healthy controls. Significantly reduced SOP by PMNs was observed in n2 and n3 cases and with se, si, sei and/or ps( + ) pathological invasion. SOP by PMNs in patients with Borrmann II type and/or poorly differentiated adenocarcinoma was significantly depressed. Patients who suffered from septic complications showed a significant depression in SOP by PMNs compared with the controls and no complication group. These results suggest that advanced gastric cancer patients may have defective oxidative PMN metabolism, and that a decrease of SOP is a contributory cause of high susceptibility to postoperative infection in cancer patients. |
| Databáze: | OpenAIRE |
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