Adjuvant effects of tilorone hydrochloride (analog 11,567) with inactivated Venezuelan equine encephalomyelitis virus vaccine
| Autor: | D. G. Harrington, C. L. Crabbs, L. E. Bolt, D. E. Hilmas, F. E. Cole, H. W. Lupton |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Encephalomyelitis
Equine Male medicine.medical_treatment Tilorone Antibodies Viral Vaccines Attenuated General Biochemistry Genetics and Molecular Biology TILORONE HYDROCHLORIDE Mice Antigen Adjuvants Immunologic Formaldehyde mental disorders medicine Animals Benzofurans Fluorenes biology business.industry Antibody titer Encephalomyelitis Venezuelan Equine Venezuelan equine encephalomyelitis virus Virology Primary and secondary antibodies Macaca mulatta Titer Immunology Antibody Formation biology.protein Female business Adjuvant Immunopotentiation |
| Zdroj: | Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 166(2) |
| ISSN: | 0037-9727 |
| Popis: | Tilorone analog 11,567 (BDD) was demonstrated to immunopotentiate Formalin-inactivated Venezuelan equine encephalomyelitis (VEE) TC-83 vaccine in mice and monkeys. The dosage of BDD required for adjuvant effects was different in mice and monkeys. In monkeys, primary and secondary antibody responses were increased (4- and 12-fold greater titers, respectively) when 10 mg/kg of BDD was given with VEE vaccine; however, 100 mg/kg of BDD had no adjuvant effect. Mice given 62 or 250 mg/kg of BDD with undiluted vaccine developed 3- and 4-fold greater antibody titers, respectively, than vaccine controls. The immunopotentiation effect of BDD was most dramatically demonstrated when graded doses (7 to 500 mg/kg) were given with a marginally antigenic dose of VEE vaccine (diluted 1:4). The BDD-vaccine combination induced antibody production, while vaccine administered without adjuvant did not. Antibody titers were significantly higher when 125 (P < 0.001) or 250 (P < 0.05) mg/kg of BDD were given with the dilu... |
| Databáze: | OpenAIRE |
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