Persistent nephrotic syndrome and focal glomerular sclerosis produced in rats by aminonucleoside and protamine
| Autor: | Takao Saito, Kei Yamakage, Takashi Furuyama, Kaoru Yoshinaga |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
medicine.medical_specialty
Nephrotic Syndrome Protamine sulfate Puromycin Aminonucleoside General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Glomerulonephritis Internal medicine medicine Animals Protamines biology Glomerulosclerosis Focal Segmental business.industry Glomerulosclerosis Rats Inbred Strains General Medicine Reduced dose medicine.disease Protamine Rats Endocrinology chemistry Puromycin biology.protein business Nephrotic syndrome medicine.drug |
| Zdroj: | The Tohoku Journal of Experimental Medicine. 138:117-118 |
| ISSN: | 1349-3329 0040-8727 |
| DOI: | 10.1620/tjem.138.117 |
| Popis: | SAITO, T., YAMAKAGE, K., FURUYAMA, T. and YOSHINAGA, K. Persistent Nephrotic Syndrome and Focal Glomerular Sclerosis Produced in Rats by Aminonucleoside and Protamine. Tohoku J. exp. Med., 1982, 138 (1), 117-118 Aminonucleoside of puromycin (AN) is known to produce nephrotic syndrome in rats. Protamine sulfate (Ps) enhanced the effect of AN. So we tried in rats four series of repeated administration of Ps in combination with AN at a reduced dose. The animals developed nephrotic syndrome and without debilitation kept it for a long time. Their kidneys demonstrated an abundance of focal glomerular sclerosis, accompanied by a notable interstitial proliferation. |
| Databáze: | OpenAIRE |
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