Dermatitis due to intravesical mitomycin C: a delayed-type hypersensitivity reaction?
| Autor: | J.A. Inglis, J.A.A. Hunter, M-J. Spencer, G.B. Colver, D.A. Tolley, Eva McVittie |
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| Rok vydání: | 1990 |
| Předmět: |
Male
Alkylating Agents Allergy Pathology medicine.medical_specialty Birbeck granules Mitomycin Urinary Bladder Antigen-Presenting Cells Dermatology Mitomycins Cystitis medicine Humans Hypersensitivity Delayed Sensitization Aged Aged 80 and over Urinary bladder business.industry Mitomycin C Middle Aged Patch Tests medicine.disease Immunohistochemistry Hypersensitivity reaction Microscopy Electron Administration Intravesical medicine.anatomical_structure Urinary Bladder Neoplasms Delayed hypersensitivity Female Drug Eruptions business Contact dermatitis |
| Zdroj: | British Journal of Dermatology. 122:217-224 |
| ISSN: | 1365-2133 0007-0963 |
| DOI: | 10.1111/j.1365-2133.1990.tb08268.x |
| Popis: | Mitomycin C is an alkylating agent, used by intravesical instillation to treat carcinoma of the bladder. Repeated instillations can induce cystitis and an eczematous eruption affecting the palms, soles and face. If these effects are due to delayed hypersensitivity with sensitization to mitomycin C occurring in the bladder wall, it should be possible to demonstrate antigen-presenting cells in the bladder wall and positive patch tests to the drug. Using an immuno-alkaline phosphatase method we have identified CDI+ cells in bladder epithelium and submucosa and have demonstrated Birbeck granules in a few cells. In further support of our hypothesis it was also possible to demonstrate delayed type hypersensitivity in 13 out of 26 patients who had received mitomycin instillations by applying the allergen as a patch test. These results indicate that the eczematous eruption in this group of patients is most likely a hypersensitivity reaction and that it may be mediated transvesically. |
| Databáze: | OpenAIRE |
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