Network topology of symbolic and nonsymbolic number comparison
| Autor: | Eric D. Wilkey, Benjamin N. Conrad, Darren J. Yeo, Gavin R. Price |
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| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
Modularity (networks) Theoretical computer science Beta-series correlation Brain activity and meditation Computer science Applied Mathematics General Neuroscience Functional connectivity Numerical cognition Modularity Neurosciences. Biological psychiatry. Neuropsychiatry Community allegiance Network topology Arabic numerals Computer Science Applications 03 medical and health sciences 0302 clinical medicine Artificial Intelligence Research Articles 030217 neurology & neurosurgery RC321-571 030304 developmental biology |
| Zdroj: | Network Neuroscience, Vol 4, Iss 3, Pp 714-745 (2020) Network Neuroscience |
| ISSN: | 2472-1751 |
| Popis: | Studies of brain activity during number processing suggest symbolic and nonsymbolic numerical stimuli (e.g., Arabic digits and dot arrays) engage both shared and distinct neural mechanisms. However, the extent to which number format influences large-scale functional network organization is unknown. In this study, using 7 Tesla MRI, we adopted a network neuroscience approach to characterize the whole-brain functional architecture supporting symbolic and nonsymbolic number comparison in 33 adults. Results showed the degree of global modularity was similar for both formats. The symbolic format, however, elicited stronger community membership among auditory regions, whereas for nonsymbolic, stronger membership was observed within and between cingulo-opercular/salience network and basal ganglia communities. The right posterior inferior temporal gyrus, left intraparietal sulcus, and two regions in the right ventromedial occipital cortex demonstrated robust differences between formats in terms of their community membership, supporting prior findings that these areas are differentially engaged based on number format. Furthermore, a unified fronto-parietal/dorsal attention community in the nonsymbolic condition was fractionated into two components in the symbolic condition. Taken together, these results reveal a pattern of overlapping and distinct network architectures for symbolic and nonsymbolic number processing. Author Summary Previous studies of local activity levels suggest that both shared and distinct neural mechanisms support the processing of symbolic (Arabic digits) and nonsymbolic (dot sets) number stimuli, involving regions distributed across frontal, temporal, and parietal cortices. Network-level characterizations of functional connectivity patterns underlying number processing have gone unexplored, however. In this study we examined the whole-brain functional architecture of symbolic and nonsymbolic number comparison. Stronger community membership was observed among auditory regions during symbolic processing, and among cingulo-opercular/salience and basal ganglia networks for nonsymbolic. A dual versus unified fronto-parietal/dorsal attention community organization was observed for symbolic and nonsymbolic formats, respectively. Finally, the inferior temporal gyrus and left intraparietal sulcus, both thought to be preferentially involved in processing number symbols, demonstrated robust differences in community membership between formats. |
| Databáze: | OpenAIRE |
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