Comparative In Vitro Activities of SMT19969, a New Antimicrobial Agent, against 162 Strains from 35 Less Frequently Recovered Intestinal Clostridium Species: Implications for Clostridium difficile Recurrence
| Autor: | Diane M. Citron, Kerin L. Tyrrell, Ellie J. C. Goldstein |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Microbial Sensitivity Tests
Gut flora Microbiology Clostridium Species Specificity Vancomycin Metronidazole RNA Ribosomal 16S medicine Cluster Analysis Pharmacology (medical) Fidaxomicin Pharmacology biology Clostridioides difficile Clostridium difficile biology.organism_classification Antimicrobial 16S ribosomal RNA Virology Anti-Bacterial Agents Infectious Diseases Aminoglycosides Susceptibility medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy |
| ISSN: | 1098-6596 0066-4804 |
| Popis: | We determined the comparative activity of SMT19969 (SMT) against 162 strains representing 35 well-characterized Clostridium species in clusters I to XIX and 13 Clostridium species that had no 16S rRNA match. SMT MICs ranged from 0.06 to >512 μg/ml and were not species related. SMT might have less impact on normal gut microbiota than other Clostridium difficile infection (CDI) antimicrobials. |
| Databáze: | OpenAIRE |
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