Can oxytocin inhibit stress-induced hyperalgesia?
| Autor: | Hong An, Yue-Xin Li, Dong-Yuan Cao, Zhuo Wen, Zhuo-Ying Tao |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Hypothalamo-Hypophyseal System
Central nervous system Analgesic Painful Stimulation Pituitary-Adrenal System 030209 endocrinology & metabolism Oxytocin 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Endocrinology medicine Animals Humans In patient Analgesics Human studies Endocrine and Autonomic Systems business.industry Stress induced Brain General Medicine medicine.anatomical_structure Neurology Hyperalgesia medicine.symptom business Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Neuropeptides. 79 |
| ISSN: | 1532-2785 |
| Popis: | Stress-induced hyperalgesia is a problematic condition that lacks an effective therapeutic measure, and hence impairs health-related quality of life. The regulation of stress by oxytocin (OT) has overlapping effects on pain. OT can alleviate pain directly mainly at the spinal level and the peripheral tissues. Additionally, OT plays an analgesic role by dealing with stress and fear learning. When OT relieves stress by targeting the prefrontal brain regions and the hypothalamic-pituitary-adrenal axis, the body's sensitivity to pain is attenuated. Meanwhile, OT facilitates fear learning and may, in turn, enhance the anticipatory actions to painful stimulation. The unique therapeutic value of OT in patients suffering from stress and stress-related hyperalgesia conditions is worth considering. We reviewed recent advances in animal and human studies involving the effects of OT on stress and pain, and discussed the possible targets of OT within the descending and ascending pathways in the central nervous system. This review provides an overview of the evidence on the role of OT in alleviating stress-induced hyperalgesia. |
| Databáze: | OpenAIRE |
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