Prevention of clinical and histological signs of proteolipid protein (PLP)-induced experimental allergic encephalomyelitis (EAE) in mice by the water-soluble carbon monoxide-releasing molecule (CORM)-A1
| Autor: | Cinzia Quattrocchi, Nuno Penacho, R. Di Marco, Carlos C. Romão, Gaetano Magro, Ferdinando Nicoletti, Katia Mangano, R. Motterlini, Paolo Fagone |
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| Rok vydání: | 2011 |
| Předmět: |
Encephalomyelitis
Autoimmune Experimental Proteolipid protein 1 Neutrophils CORM-A1 Encephalomyelitis Immunology Carbonates Inflammation Dexamethasone animal models carbon monoxide-releasing molecules CORM-A1 experimental allergic encephalomyelitis SJL mice Mice SJL mice medicine Animals Immunology and Allergy Cumulative incidence Boranes Myelin Proteolipid Protein Carbon Monoxide carbon monoxide-releasing molecules business.industry Experimental allergic encephalomyelitis Multiple sclerosis Anti-Inflammatory Agents Non-Steroidal Body Weight Experimental autoimmune encephalomyelitis medicine.disease Carbon monoxide-releasing molecules Peptide Fragments animal models carbon monoxide-releasing molecules CORM-A1 Spinal Cord Female medicine.symptom business medicine.drug |
| Zdroj: | Clinical and Experimental Immunology. 163:368-374 |
| ISSN: | 1365-2249 0009-9104 |
| DOI: | 10.1111/j.1365-2249.2010.04303.x |
| Popis: | Summary We have evaluated the effects of the carbon monoxide-releasing molecule CORM-A1 [Na2(BH3CO2); ALF421] on the development of relapsing–remitting experimental allergic encephalomyelitis (EAE) in SJL mice, an established model of multiple sclerosis (MS). The data show that the prolonged prophylactic administration of CORM-A1 improves the clinical and histopathological signs of EAE, as shown by a reduced cumulative score, shorter duration and a lower cumulative incidence of the disease as well as milder inflammatory infiltrations of the spinal cords. This study suggests that the use of CORM-A1 might represent a novel therapeutic strategy for the treatment of multiple sclerosis. |
| Databáze: | OpenAIRE |
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